师资介绍 于广利教授

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于广利教授

( \ C3 R j& d; c! ~个人简介: 于广利， 男， 1964年12月生，博士，教授, 博士生导师。主要从事多糖（寡糖）及糖复合物的教学与研究工作，为中国药学会高级会员。于1999－2000年美国IOWA大学药学院Robert J Linhardt教授实验室从事肝素与类肝素寡糖的结构与活性关系研究。 师从管华诗院士和Robert J Linhardt教授。自1998年以来, 先后参与完成美国NIH课题，国家863，国家青年基金863，国家海洋青年863，国家95攻关，农业部95攻关，国家科技部重点项目，中加合作项目以及山东省、青岛市科技局等项目20项，在研项目有4项，其中国家自然科学基金2项，国家973基础研究子课题1项，青岛市科技局项目1项。国家海洋863和国家青年863各1项。共发表与糖类研究文章50余篇，其中SCI收录19篇，申请国家发明专利18项，授权9项，编写本科教材1部。 i2 {& E% o& a4 o) E b : [! K3 h3 S7 i+ b8 z. l' x研究方向以及主要研究内容： 1．从事以海洋生物（包括海洋动物、植物和微生物）为主的糖类新资源的研究与开发； ' l" v' G" r7 @0 P0 o* O& x2．从事海洋多糖与寡糖生物芯片制备技术及其生物活性固相检测方法研究； 3．从事人类重大疾病的发生发展过程中糖链细微结构的变化规律研究； # d( y& a7 N6 o, ^2 z2 }4．从事以糖类药物为主的糖工程化药物及其质量标准研究； / L P; n, s1 u' d+ f5．从事海洋生物多糖之外的其它多糖及其复合物的提取分离和结构研究。 研究论文： 1. Guangli Yu, Xia Zhao, Bo Yang, Sumei Ren, Huashi Guan, Yibing Zhang, Alexander M. Lawson, and Wengang Chai. Sequence Determination of Sulfated Carrageenan-Derived Oligosaccharides by High-Sensitivity Negative-Ion Electrospray Tandem Mass Spectrometry. Analytical Chemistry, 2006, 78，8499－8505 (SCI, IF 5.45) 2. Zhenqing Zhang, Guangli Yu, Xia Zhao, Haiying Liu, Huashi Guan, Alexander M. Lawson, Wengang Chai. Sequence analysis of alginate-derived oligosaccharides by negative-ion electrospray tandem mass spectrometry, Journal of the American Society for Mass Spectrometry, 2006, 17，621－630 (SCI, IF 3.76) 3. & }& j; {1 s8 o9 T* i7 ^WangYuanhong，Yu Guangli，Wang Xinmin, LV Zhihua, Zhao Xia, Wu Zhihong, Ji Weishang, Purification and Characterization of alginate lyase from marine Vibro sp YWA, Acta Biochimica et Biophysica Sinaca, 2006,38(9):633-638 (SCI, IF 0.81) 4. Lv Zhihua, Sun Yan, Wang Yuanhong, Jiang Tingfu, Yu Guangli, Ultrasensitive Capillary Electrophoresis of Oligoguluronates with Laser-Induced Fluorescence Detection，Chromatographia, 2005, 61:615-618. （SCI, IF1.145） , Q/ F. W2 Q$ y4 c/ T! \6 T0 Y4 D& G5. Zhang Zhenqing, Yu Guangli*, Guan Huashi, Zhao Xia, Du Yuguo, Preparation and structure elucidation of alginate oligosaccharides degraded by alginate lyase from Vibro Sp 510. Carbohydrate research, 2004, 339(8),1475-81. (SCI) # A7 _5 x0 r; c4 K: a6. Yuxia Hua, Yuguo Du, Guangli Yu, Shidong Chu. Synthesis and biological activities of octyl 2,3-di-O-sulfo-α-l-fucopyranosyl-(1→3)-2-O-sulfo-α-l-fucopyranosyl-(1→4)-2,3-di-O-sulfo-α-l-fucopyranosyl-(1→3)-2-O-sulfo-α-l-fucopyranosyl-(1→4)-2, 3-di-O-sulfo-β-l-fucopyranoside. Carbohydrate research, 2004,339(12):2083-2090. (SCI) 7. 3 B: s5 ?* e; v5 e- s( c8 PYuguo Du, Guofeng Gu, Yuxia Hua, Guohua Wei, Xinshan Ye, Guangli Yu, Synthesis and antitumor activities of glucan derivatives. Tetrahedron. 2004, 60（30）：6345－6351. (SCI) 6 X ?7 p$ F" W3 y: j" e& y8. , U/ Q, B+ l+ R E; }4 V0 M7 Q$ M* qGuangli Yu, Huashi Guan, Alexandra S. Ioanoviciu, Sulthan A. Sikkander, Charuwan Thanawiroon, Joanne K. Tobacman, Toshihiko Toida, Robert J. Linhardt. Structural Studies on k-Carrageenan Derived Oligosaccharides. Carbohydrate Research. 2002, 337(5): 433-440. (SCI) (1.63) 9. 2 l/ @( {4 u* u7 ^8 F2 cGuangli Yu, Nur Sibel Gunay, Robert J. Linhardt, Toshihiko Toida, Jawed Fareed et al. Preparation and anticoagulant activity of the phosphosulfomannan PI88. - A, C) @* w! a( l1 dEuropean J. of Med. Chem., 2002, 37(10): 783-791 (SCI, 1.705) 10.Guangli Yu, laurie Lebrun Nue Sibel Gunny, R. J. Linhardt. Heparinase I acts on a synthesis heparin-derived corresponding to the antithrombin III binding site,. Thrombosis Research. 2000, 100(6): 549-556. (SCI, 9 Q: D1 l8 |( }3 ]# L1.494) * }3 g" M. j# D

11.Hyun OK Yang, Nur Sibel Gunny, Toshihiko Toida, Kuberan, Guangli Yu, R. J. Linhardt. Preparation and Strucure determination of dermatan sulfated-derived oligosaccharide. Glycobiology, 2000,10(10): 033-1039. (SCI, 3.45)